Rapid Healing and Reduced Erythema after Ablative Fractional Carbon Dioxide Laser Resurfacing Combined with the Application of Autologous Platelet-Rich Plasma
Significantly faster recovery of TEWL was seen on the PRP-treated side. The erythema index and melanin index on the PRP-treated side were lower than on the control side. Biopsy specimens from the PRP-treated side showed thicker collagen bundles than those from the control side.
Application of autologous PRP is an effective method for enhancing wound healing and reducing transient adverse effects after FxCR treatment.
Platelet-rich plasma and hyaluronic acid – an efficient biostimulation method for face rejuvenation.
There was a statistically significant difference in general appearance, skin firmness-sagging and skin texture according to the patients’ before and after applications of PRP. A statistically significant correlation was found between the number of injections and overall satisfaction.
Compared to the baseline, the PRP and HA injections provided clinically visible and statistically significant improvement on facial skin. The improvements were more remarkable as the injection numbers increased.
Histologic Evidence of New Collagen Formulation Using Platelet Rich Plasma in Skin Rejuvenation: A Prospective Controlled Clinical Study
Twenty women ranging in age from 40 to 49 years (mean age, 43.65±2.43 years) were enrolled in the study. The mean optical densities (MODs) of collagen in the pre-treatment, control, and PRP-treated area were measured. They were 539±93.2, 787±134.15, 1,019±178, respectively. In the MOD of PRP, 89.05 percent improvement was found when MOD of PRP was compared with MOD of pre-treatment. The mean MOD of collagen fibers was clearly highest on the PRP side (p<0.001). The PRP-to-saline improvement ratio (89.05% to 46.01%) was 1.93:1. No serious side effects were detected.
PRP increases dermal collagen levels not only by growth factors, but also by skin needling (the mesotherapy technique ‘point by point’). PRP application could be considered as an effective (even a single application) and safety procedure for facial skin rejuvenation.
The Clinical Efficacy of Autologous Platelet-Rich Plasma Combined with Ultra-Pulsed Fractional CO2 Laser Therapy for Facial Rejuvenation
Patients in the experimental group had faster recovery, less duration of adverse events, and better effects than that in the control group. No other side effects such as petechia, pigmentation, effusion, infection, keloid, blisters, and contact dermatitis were found after treatment. In the process of treatment, patients felt that searing pain caused by laser therapy was relieved by coating with PRP. In summary, combined application could not only effectively reduce facial wrinkles and texture, but also significantly relieve the coarse pores, pigmentation, and erythema caused by laser therapy. PRP and ultra-pulsed fractional CO2 laser had a synergistic effect on the therapy for facial rejuvenation.